While Omeprazole (a PPI) can be effective, studies show it helps reduce symptoms in only 25-80% of people. Since your son is still experiencing pain after 3 weeks, it's important to discuss additional treatment options with his gastroenterologist. They may consider:

- Topical steroids like fluticasone or budesonide
- Biologic therapies like dupilumab (for patients 12 and older)
- Adjustments to the elimination diet approach
- Further allergy testing to identify specific trigger foods It's crucial to stay well hydrated throughout the day to help manage symptoms. When taking any medications, always take them with plenty of water to avoid irritating the esophagus further. If pain persists, your son's doctor may need to reassess his treatment plan or consider additional medications to better control the inflammation causing his discomfort.