Chest pain and heartburn that doesn't respond well to PPIs can be symptoms of EoE. Adults with EoE often experience:

• Intense acid reflux
• Pain in the center of the chest
• Difficulty swallowing (dysphagia)
• Food getting stuck in the esophagus
• Stomach pain
• Vomiting While these symptoms could indicate EoE, only proper testing can confirm a diagnosis. If PPIs aren't helping after extended use, it's important to talk to your doctor about getting evaluated specifically for EoE. This typically involves an upper endoscopy with a biopsy to examine for increased eosinophils in your esophagus.